Supportive Oligonucleotide Therapy (SOT), also known as Antisense Oligodeoxynucleotide Therapy (AOT), is an advanced, precision-based treatment used in functional and integrative medicine to address chronic infections and certain cancers at the genetic level.
At Integrative Wellness FX, we offer SOT to patients throughout Dallas–Fort Worth, using a highly personalized process designed to target the exact genetic drivers of infection or cancer in each individual.
SOT Therapy in Dallas/Ft. Worth
What Is Supportive Oligonucleotide Therapy (SOT)?
Rather than stimulating or suppressing the immune system, SOT works by blocking a critical gene, preventing the target cell from producing essential proteins. When that gene is silenced, the cell can no longer survive and undergoes apoptosis, or programmed cell death.
Once administered intravenously, SOT remains active in the body for approximately six months, working continuously to eliminate the targeted cells.
Chronic Pain and Inflammation
Poor mitochondrial function increases oxidative stress, meaning free radicals accumulate faster than the body can neutralize them. This drives inflammation across tissues.
In the nervous system, inflammation can cause nerve hypersensitivity and exaggerated pain signaling even when imaging shows no structural injury. In muscles and connective tissue, mitochondrial dysfunction often appears as soreness, stiffness, or fibromyalgia-type pain.
Thyroid Cancer
Thyroid cancer is the growth of malignant cells in the thyroid gland. Symptoms may include a lump in the neck, changes in voice, and difficulty swallowing. The cause multifactorial and due to the oxidative stress from numerous sources, but genetic factors and exposure to radiation can also increase risk.
The Science Behind SOT Therapy
How Antisense Oligonucleotides Work
DNA and RNA are made from nucleotides, the basic building blocks of genetic material. “Oligo” means few, and oligonucleotides are short nucleotide sequences, typically fewer than 20 bases. An antisense oligonucleotide is designed to bind to a specific messenger RNA (mRNA) sequence in a target cell.
When mRNA is bound by an antisense strand, it cannot bind to the ribosome. The protein encoded by that gene cannot be produced, making the gene nonfunctional. Blocking a critical gene causes the target cell to self-destruct.
In cancer applications, SOT targets genes responsible for anti-apoptotic signaling, removing the cancer cell’s ability to avoid programmed cell death.
How RGCC Creates a Personalized SOT
The process includes drawing the patient’s blood at our Dallas–Fort Worth clinic, isolating pathogens or circulating tumor cells, identifying the primary replication or survival gene, cross-referencing gene sequences with international genetic databases, and creating a perfectly matched antisense “anti-copy” strand.
The antisense strand is surrounded by a synthetic messenger RNA shell that enables it to penetrate the target cell wall. This compound is replicated into approximately 500 million to 1 billion identical SOT molecules and shipped back to the clinic for administration.
SOT does not interfere with healthy human cells, tissues, or organs.
Chronic Pain and Inflammation
Poor mitochondrial function increases oxidative stress, meaning free radicals accumulate faster than the body can neutralize them. This drives inflammation across tissues.
In the nervous system, inflammation can cause nerve hypersensitivity and exaggerated pain signaling even when imaging shows no structural injury. In muscles and connective tissue, mitochondrial dysfunction often appears as soreness, stiffness, or fibromyalgia-type pain.
Thyroid Cancer
Thyroid cancer is the growth of malignant cells in the thyroid gland. Symptoms may include a lump in the neck, changes in voice, and difficulty swallowing. The cause multifactorial and due to the oxidative stress from numerous sources, but genetic factors and exposure to radiation can also increase risk.
Cost of SOT Therapy at Integrative Wellness Fx
Safety and Side Effects
Other natural or antiviral treatments do not negatively affect SOT effectiveness.
Treatment Frequency and Timing
After results are received, a single SOT protocol is selected based on the identified gene patterns. Only one type of SOT may be used at a time, either cancer or infection. Mixing different SOT therapies too closely together is not recommended due to the risk of cross-reaction.
The SOT is administered via intravenous infusion at our clinic. After infusion, the therapy works continuously for approximately six months.
Follow-up testing is strongly recommended to confirm resolution of infection or to monitor reduction in circulating cancer stem cells.
How the SOT Protocol Works
SOT is also used in integrative cancer care to target circulating tumor cells and cancer stem cells by inducing apoptosis. It can be used alongside conventional, integrative, or natural cancer therapies without interference.
What Conditions Can SOT Be Used For?
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