You may have heard that the first sign of Lyme disease is a bullseye-shaped rash. But what if we told you that up to 30% of people with Lyme disease never develop a visible rash at all. That means even if you don’t remember a tick bite or never saw a bullseye rash, Lyme disease is still a possibility.

This is one of the reasons Lyme disease is frequently missed in its early stages. Symptoms can be vague, inconsistent, and easily mistaken for other conditions such as the flu, autoimmune disease, chronic fatigue, or anxiety. Because of this, Lyme disease has earned the nickname “The Great Imitator.”

At Integrative Wellness FX, we provide advanced functional medicine–based Lyme disease care for patients across Dallas–Fort Worth and throughout Texas via telehealth, helping individuals who have struggled for months or even years without clear answers.

Lyme Disease Doctor in Dallas/Ft. Worth

Signs and Symptoms of Lyme Disease

Lyme disease symptoms vary widely depending on how long the infection has been present and how well the immune system is functioning.

Acute Lyme Disease Symptoms
Early Lyme disease may present with symptoms such as persistent fatigue, migratory muscle and joint pain that moves from area to area, headaches, neck pain or stiffness, memory or concentration challenges, and sleep disturbances.
Because these symptoms overlap with many common illnesses, Lyme disease is often overlooked or misdiagnosed during this stage.

Chronic Lyme Disease Symptoms
When Lyme disease goes undetected or does not fully respond to initial treatment, it can become chronic. Chronic Lyme disease can affect nearly every system in the body and may include depression, anxiety, or mood swings, brain fog, slowed thinking, cognitive decline or Alzheimer’s-like symptoms, neuropathy including numbness or tingling, immune dysfunction, and cardiovascular symptoms such as chest pain, palpitations, or shortness of breath.
At this stage, many patients are told their symptoms are unrelated or psychological, leaving the underlying infection untreated.

Chronic Fatigue and Low Energy

Fatigue develops because cells are literally low on fuel. To compensate, the body slows metabolism and downregulates non-essential functions. Over time, this leads to persistent exhaustion that does not improve with rest.

Chronic Pain and Inflammation

Poor mitochondrial function increases oxidative stress, meaning free radicals accumulate faster than the body can neutralize them. This drives inflammation across tissues.
In the nervous system, inflammation can cause nerve hypersensitivity and exaggerated pain signaling even when imaging shows no structural injury. In muscles and connective tissue, mitochondrial dysfunction often appears as soreness, stiffness, or fibromyalgia-type pain.

Hyperthyroidism

Hyperthyroidism is characterized by excessive production of thyroid hormones, causing symptoms like rapid weight loss, anxiety, irritability, and heat intolerance. Common causes include autoimmune disorders, such as Graves' disease, and thyroid nodules.

Goiter

A goiter is an abnormal enlargement of the thyroid gland, which can occur due to iodine deficiency, Hashimoto's thyroiditis, or Graves' disease. Symptoms can include swelling at the base of the neck, difficulty swallowing, and breathing issues.

Thyroid Cancer

Thyroid cancer is the growth of malignant cells in the thyroid gland. Symptoms may include a lump in the neck, changes in voice, and difficulty swallowing. The cause multifactorial and due to the oxidative stress from numerous sources, but genetic factors and exposure to radiation can also increase risk.

How Lyme Disease Causes Widespread Symptoms

Lyme disease is caused by the bacterium Borrelia burgdorferi, which disrupts normal physiology through multiple mechanisms.

Borrelia Drives Chronic Inflammation

Borrelia burgdorferi triggers a powerful inflammatory response by releasing pro-inflammatory cytokines. This inflammation can affect joints, muscles, nerves, the brain, and the cardiovascular system. Neuroinflammation is strongly associated with brain fog, depression, anxiety, and cognitive decline.

Borrelia Suppresses the Immune System

Borrelia actively downregulates immune function, allowing it to persist in the body while remaining difficult to detect. This immune suppression increases vulnerability to additional infections and reduces the body’s ability to clear the bacteria.

Borrelia May Trigger Autoimmunity

Through molecular mimicry, antibodies created to fight Borrelia may cross-react with the body’s own tissues. This helps explain why chronic Lyme disease has been associated with autoimmune and neurodegenerative conditions such as multiple sclerosis, rheumatoid arthritis, and Alzheimer’s disease.

Why Lyme Disease Is So Difficult to Treat

Lyme disease is complex and notoriously difficult to eradicate with standard antibiotic protocols.

Borrelia impairs both adaptive immunity and the complement system, weakening the body’s natural defenses. It can also change its shape from its spiral form into cystic structures that lack recognizable surface proteins, allowing it to evade immune detection.

Borrelia frequently forms biofilms, often alongside other microbes. These biofilms act as protective shields that make bacteria far more resistant to antibiotics. In addition, Borrelia rapidly alters gene expression in response to common antibiotics such as doxycycline, amoxicillin, and ceftriaxone. These changes allow the bacteria to enter dormant “persister” states and survive treatment, leading to relapse.

The Role of Co-Infections in Chronic Lyme Disease

Ticks often carry multiple pathogens in addition to Borrelia burgdorferi. These co-infections can intensify symptoms and complicate treatment.

Common Lyme co-infections include Bartonella, which may cause joint pain, abdominal pain, sore throat, and neuropsychiatric symptoms; Babesia, often associated with anxiety, night sweats, air hunger, and heart palpitations; Mycoplasma, which is strongly linked to autoimmune reactions; Rickettsia, which can cause flu-like symptoms and rashes on the palms or soles; and Chlamydia species, which may contribute to respiratory infections and autoimmune disease.

Identifying and addressing co-infections is essential for successful Lyme disease treatment.

The Functional Medicine Approach to Lyme Healing

Chronic Lyme disease requires more than symptom management. Healing is possible, but it requires an intelligent, systematic approach and consistency over time.

Many people carry Lyme or co-infections without becoming ill. Those who develop chronic symptoms often have underlying factors that weaken immune resilience, such as mold toxicity, heavy metal exposure, parasites, leaky gut, nutrient deficiencies, or chronic stress.

Functional medicine focuses on identifying and correcting these immune stressors first. By strengthening the immune system at the root level, antimicrobial therapies become far more effective and sustainable.

Once immune resilience is restored, treatment may include targeted antimicrobial herbs, immune-supportive nutrients, and personalized supplement protocols. Treating infection before rebuilding immune function often leads to relapse, wasted time, and microbial resistance.

Chronic Fatigue and Low Energy

Fatigue develops because cells are literally low on fuel. To compensate, the body slows metabolism and downregulates non-essential functions. Over time, this leads to persistent exhaustion that does not improve with rest.

Chronic Pain and Inflammation

Poor mitochondrial function increases oxidative stress, meaning free radicals accumulate faster than the body can neutralize them. This drives inflammation across tissues.
In the nervous system, inflammation can cause nerve hypersensitivity and exaggerated pain signaling even when imaging shows no structural injury. In muscles and connective tissue, mitochondrial dysfunction often appears as soreness, stiffness, or fibromyalgia-type pain.

Hyperthyroidism

Hyperthyroidism is characterized by excessive production of thyroid hormones, causing symptoms like rapid weight loss, anxiety, irritability, and heat intolerance. Common causes include autoimmune disorders, such as Graves' disease, and thyroid nodules.

Goiter

A goiter is an abnormal enlargement of the thyroid gland, which can occur due to iodine deficiency, Hashimoto's thyroiditis, or Graves' disease. Symptoms can include swelling at the base of the neck, difficulty swallowing, and breathing issues.

Thyroid Cancer

Thyroid cancer is the growth of malignant cells in the thyroid gland. Symptoms may include a lump in the neck, changes in voice, and difficulty swallowing. The cause multifactorial and due to the oxidative stress from numerous sources, but genetic factors and exposure to radiation can also increase risk.

Advanced Therapies for Chronic Lyme Disease

At Integrative Wellness FX, advanced therapies may be incorporated strategically throughout the healing process.

Support Oligonucleotide Therapy (SOT) is a precision RNA-based therapy designed to silence microbial replication genes and initiate programmed cell death. SOT remains active for approximately six months and is often used later in care to deliver a decisive antimicrobial effect.

Additional therapies may include ozone therapy, advanced peptide therapy, hyperbaric oxygen therapy, infrared sauna therapy, and detoxification support. These modalities help reduce microbial load, improve oxygen delivery, enhance detox pathways, and accelerate recovery.

Borrelia Drives Chronic Inflammation

Borrelia burgdorferi triggers a powerful inflammatory response by releasing pro-inflammatory cytokines. This inflammation can affect joints, muscles, nerves, the brain, and the cardiovascular system. Neuroinflammation is strongly associated with brain fog, depression, anxiety, and cognitive decline.

Borrelia Suppresses the Immune System

Borrelia actively downregulates immune function, allowing it to persist in the body while remaining difficult to detect. This immune suppression increases vulnerability to additional infections and reduces the body’s ability to clear the bacteria.

Borrelia May Trigger Autoimmunity

Through molecular mimicry, antibodies created to fight Borrelia may cross-react with the body’s own tissues. This helps explain why chronic Lyme disease has been associated with autoimmune and neurodegenerative conditions such as multiple sclerosis, rheumatoid arthritis, and Alzheimer’s disease.

Poor Gut Health and Microbial Imbalance

Gut dysfunction strongly impacts mitochondrial health. Dysbiosis, leaky gut, and endotoxins like lipopolysaccharides can enter circulation and trigger systemic inflammation, placing additional stress on mitochondria.

Chronic Stress and Cortisol Dysregulation

Long-term stress elevates cortisol and inflammatory signaling. Over time, this suppresses mitochondrial biogenesis—the formation of new mitochondria—and increases free radical production.

Sleep Deprivation and Circadian Disruption

Mitochondria repair and regenerate during deep, restorative sleep. Poor sleep quality, irregular schedules, and circadian rhythm disruption blunt this repair process and accelerate mitochondrial decline.

Electromagnetic and Oxidative Stress

Excess EMF exposure, poor air quality, and smoking increase oxidative stress, damaging mitochondrial membranes and impairing ATP production.

Recovering from Lyme disease is not simple or quick, but people do get better when the right steps are taken in the proper order and followed consistently.

Integrative Wellness FX offers advanced functional medicine–based Lyme disease care for patients in Dallas, Fort Worth, and across Texas through telehealth. Our approach is personalized, science-driven, and designed to restore immune resilience at the root level.

If you suspect Lyme disease or have been living with chronic, unexplained symptoms, we invite you to take the next step.

Schedule a consultation with Integrative Wellness FX and begin a smarter, more effective path to healing.

Lyme Disease Treatment in Dallas/Fort Worth

Dr. David and the entire Integrative Wellness Fx team are passionate about sharing their expertise to empower you with knowledge supportive of your holistic health & lifestyle.

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